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Clinical Studies

Multiple, peer-reviewed, published studies have shown the effect that Silverlon can have. Studies in a wide variety of Surgical, Wound and Burn Care settings. Explore the studies behind the most advanced, evidence-based antimicrobial dressings available today.

Decreasing Utilization of Indwelling Urinary Catheters Using Creative Strategies

Authors: Jeannine W.C. Blake, PhD RN1; Ellie Milo, DNP RN CENP NEA-BC2; Robert Garcia, BS, MT(ASCP), CIC, FAPIC3

Christus Santa Rosa Hospital

Publication: Elaine Mareib Center for Nursing and Engineering Innovation, University of Massachusetts Amherst; Chief Nursing Officer, Christus Santa Rosa Westover Hillss; Enhanced Epidemiology LLC

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PEG TUBE DISLODGEMENT: REDUCING HARM THROUGH INNOVATIVE PRODUCT
AND PROCESS CHANGE

Authors: Amanda Ross, RN; Jeannine Blake, PhD RN

Memorial Hermann Southwest

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ECMO Care Beyond Decannulation: A Nurse Driven Wound Care Protocol

Authors: Audrey Basic1, Emily Smith1, Jonathon Holte2, Sylvie Baudart3, Jason Smith4 

University of California at San Francisco

Publication: Intensive Cardiac Care1, Institute for Nursing Excellence2,Mechanical Circulatory Support3, Department of Cardiothoracic Surgery4

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A Silver Lining in the VAD Sky: A Prospective Randomized Controlled Driveline Dressing Study

Authors: Sylvie Baudart1, Liviu Klein2

University of California at San Francisco

Publication: Department of Mechanical Circulatory Support, Advanced Heart Failure Comprehensive Care Center

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Modified Sodium Hypochlorite Wound Cleansing for Chronic Wounds: Focused Clinical Literature Review

Authors: Karen K. Giuliano, RN, PhD1, Bill Richlen PT, WCC, DWC2, Charlie P. Buscemi, PhD, APRN, CWCN, WOCNF3

University of Massachusetts Amherst; Wound Care Gurus; Florida International University. Miami, FL

Publication: Florida International University

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Silver-Plated Wound Dressings for the Management of Radiation Dermatitis in Head and Neck Cancer

Authors: Cody R Kilar, DO, PhD1, Christopher Knoth, MD2, Alexis Warden PA-C3, David A Clump, MD, PhD4

Department of Radiation Oncology, West Virginia University Cancer Institute, Morgantown, West Virginia

Publication: WVU Cancer Institute 

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Patient Perspectives on Novel Intervention for Radiation Dermatitis

Authors: Phylicia Gawu, D.O.1, Oluwatomiwa Awobayiku, BS2, Alekhya Mitta M.D.3, Christina Henson M.D.4

The University of Oklahoma Health Sciences Center, Stephenson Cancer Center; New York Institute of Technology College of Osteopathic Medicine at Arkansas State University

Publication: InitialPatient Perspectives on a Novel Intervention for Radiation Dermatitits: A Single Institutional Experience 

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Silverlon: A Weapon Against Driveline Infections in Lvad Patients

Authors:K.R. Barrett,1 B. Ebert,2 and M. Remaly.3

Lehigh Valley Health Network, Allentown, PA; Lehigh Valley Health Network, Harleysville, PA; and the Lehigh Valley Hospital, Germansville, PA.

The Journal of Heart and Lung Transplantation, Vol 42, No 4S, April 2023

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Use of a Silver Nylon Dressing Following Total Hip and Knee Arthroplasty Decreases the Postoperative Infection Rate

Authors: Ashley J. Tisosky MD1, Otatade Iyoha-Bello BSc2, Nicholas Demosthenes BA3, Giovanni Quimbayo MD2, Tara Coreanu BSc4, Ayesha Abdeen MD FRCSC5

Harvard Combined Orthopaedic Residency Program, Massachusetts General Hospital, Boston, MA, USA

Publication: JAAOS - Journal of the American Academy of Orthopaedic Surgeons (2017)

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The Use of Silver Nylon in Preventing Surgical Site Infections Following Colon and Rectal Surgery

Authors: Beth Krieger MD, Donald M. Davis MD, Jaime E. Sanchez MD, James J. Mateka, Valentine N. Nfonsam MD, Jared C. Frattini MD, Jorge E. Marcet MD

University of South Florida, Tampa, FL, USA 

Publication: Diseases of the Colon & Rectum (2011)

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surgical

A Clinical Trial to Investigate the Effect of Silver Dressings on Mediastinitis Rates in Postoperative Cardiac Sternotomy Incisions

Authors: Roger Huckfeldt MD FACS, Clyde Redmond MD, Debbie Mikkelson BSM, Phillip J. Finley MS, Cindy Lowe BS CCRP, Jennifer Robertson RN

St John’s Regional Health Center, Springfield, MO, USA

Publication: Ostomy Wound Management (2008)

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surgical

Reduction in Central Line–Associated Bloodstream Infections Correlated With the Introduction of a Novel Silver-Plated Dressing for Central Venous Catheters and Maintained for 6 Years

Authors: Rachel Karlnoski PhD1, Elia Charbel Abboud MD1, Peggy Thompson BSN CIC FAPIC2, Asa Z. Oxner MD3, John T. Sinnott, MD FACP4, Jorge E. Marcet MD FACS FASCRS1

Tampa General Hospital, Tampa, FL, USA 

Publication: Journal of Intensive Care Medicine (2017)

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Do Silver-Impregnated Dressings Limit Infections After Lumbar Laminectomy with Instrumented Fusion?

Author: Nancy E. Epstein MD

Albert Einstein College of Medicine, Bronx, NY, USA

Publication: Surgical Neurology (2007) 

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surgical

Left Ventricular Assist Devices: An Innovative Approach to Decrease Infections Using a Silver Contact Dressing

Author: Joan Lerner Selekof BSN RN CWOCN

University of Maryland Medical Center, Baltimore, MD, USA

Presented at Mid Atlantic Region Wound Ostomy and Conference Nurses Annual Conference (2010)

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surgical

Healing Chronic, Ischemic, Infected Saphenous Vein Harvest Sites in the Legs with Silver Plated Cloth and Allograft Dermal Regenerative Matrix

Authors: Stanley Carson MD FACS, Eric Travis DPM, Carol Ajifu PT, DIana To MPT

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surgical

Clinical Case Evaluation and Results of Silverlon® Sternal Dressings in Cardiac Surgery

Author: Brian W. Hummel, M.D., F.A.C.S.

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surgical

Silver Negative Pressure Dressing With Vacuum-assisted Closure of Massive Pelvic and Extremity Wounds

Authors: Herrick J. Siegel MD, Diego F. Herrera MD, Jason Gay CRNFA

University of Alabama at Birmingham (UAB), Birmingham, AL, USA

Publication: Clinical Orthopaedics and Related Research (2013)

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negative-pressure-wound-therapy, wounds

Military Applications of Silver-Nylon Dressings

Author: David J Barillo MD FACS FCCM

Winchester Medical Center, Winchester VA, USA 

Publication: BURNS: The Journal of the International Society of Burn Injuries (2014) 

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military

A Clinical Evaluation of Silverlon® Wound Contact Layer Antimicrobial Wound Dressing

Author: Gareth Owen

Manchester Royal Infirmary, UK

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wounds

Silverlon® use in Afghanistan for Burn Care

Authors: Mary-Margaret Brandt MD, Margaret Tait MT (ASCP), Thomas Toddanio MA MT (ASCP), Wendy Wahl MD

University of Michigan Burn Center, MI, USA

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military, burns

Comparison of Silverlon® Dressing to Xeroform Gauze in the Treatment of Skin Graft Donor Site Wounds

Authors: Michale C. Albrecht MD, Evan Renz MD, Leopoldo C. Cancio MD, Christopher E. White MD, Lorne H. Blackbourne MD, Kevin Chung MD, Eric E. Horvath DO, Peggy Bielke RN, David Baer PhD, Steven E. Wolf MD, John B Holcomb MD

U.S. Army Institute of Surgical Research, Fort Sam Houston, TX, USA

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burns, military

Chronic, Diabetic Foot Wounds with Ischemia and Tissue Loss: Use of Advanced Wound Care Techniques, Silver Plated Cloth, Allografts and Vascular Intervention to Prevent Further Tissue Loss

Authors: Dr. Stanley N. Carson MD FACS, Eric Travis DPM, Diana To MPT

Fountain Valley Regional Hospital, Fountain Valley, CA, USA

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wounds

Treatment of Pyoderma Gangrenosum with a Silver Contact Layer

Author: Dr. Carl Van Gils

Dixie Regional Medical Center Wound Clinic, St. George, UT, USA

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wounds

Do Silver-Based Wound Dressings Reduce Pain?  A Prospective Study and Review of the Literature

Author: Elia Charbel Abboud, Timmothy B. Legare, Judson C. Settle, Amir M. Boubekri, Jorge E. Marcet, and Jaime

Sanchez - University of South Florida, Tampa, Florida, USA and David J Barillo, MD, FACS, FCCM - Mount Pleasant, South Carolina, USA

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surgical

Silverlon® Burn Products Continuum of Burn Care

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burns

Comparison Silverlon® and Acticoat™ Zones of Inhibition

Author: JP Heggers, Journal of Burns

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burns

Use of Pure Metallic Silver – Plated to Nylon Dressing for: Recalcitrant Wounds

Author: Mary Foote, RN MSN ANP CWCN

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wounds

Successful Treatment of a Chronic Venous Ulcer with a Silver Contact Dressing

Author: Carol Publicover MSN, ARNP, CWOCN

Florida Hospital Wound Management Centers

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wounds

Clinical Case Study – Treatment of Coumadin Tissue Necrosis with Silverlon®

Author: Cathy Rogers, APRN, BC, CWCN

SwedishAmerican Hospital Wound Care Clinic

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wounds

An Innovative Approach Using Silver Contact Dressing To Manage Grade IV Skin Lesions

Author: University of Maryland Medical Center

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wounds

Silver Antimicrobial Wound Dressings Cost Comparison

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wounds

Non-Inferiority of a Novel Silver-Plated Dressing for Central Venous Catheters: A Retrospective Cohort Evaluating Rates of Central Line-Associated Bloodstream Infections in Adult Intensive Care Patients

U. of South Florida College of Medicine / Tampa General Hospital

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wounds

Silver Dressings Used With Wound Vacuum Assisted Closure: Is There an Advantage?

Author: Dr. Stanley Carson

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negative-pressure-wound-therapy

Healing Skin Grafts over Chronic Wounds with Vacuum Assisted Closure* and Silver Dressings**

Author: Dr. Stanley Carson

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negative-pressure-wound-therapy

Comparison of Healing of Lower Extremity Chronic Wounds with Silver Plated Cloth Dressings, Papain-Urea-Chlorophyllin Ointment and Hydrogel

Author: Dr. Stanley Carson

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negative-pressure-wound-therapy

The Combined Benefit of Negative Pressure Therapy (N.P.T.)

Author: Dr. Stanley Carson

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negative-pressure-wound-therapy

Silver in Medicine: A Brief History BC 335 to Present

Authors: David E. Marx DVM, David J Barillo MD FACS FCCM

University of Scranton, Scranton, PA, USA

Publication: BURNS: The Journal of International Society of Burn Injuries (2014) 

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Silver-Resistance, Allergy, and Blue Skin: Truth or Urban Legend?

Author: Dr. Jose P. Sterling, MD

St. Vincent Regional Medical Center, Santa Fe, NM, USA

Publication: BURNS: The Journal of the International Society of Burn Injuries (2014)
 

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surgical, central-line-catheter, wounds, negative-pressure-wound-therapy, burns-and-military, silver-in-medicine

Silver Toxicity and Resistance in Wound Care

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in-vitro

Silver In Medicine: The Basic Science

Authors: David J Barillo, MD FACS FCCM, David E. Marx DVM

University of Scranton, Scranton, PA, USA

Publication: BURNS: The Journal of International Society of Burn Injuries (2014) 

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Safety evaluation of silver-ion dressings in a porcine model of deep derman wounds: a GLP study

Authors: David J. Barillo, Claire R. Croutch, Anthony R. Barillo, Frances Reid, Al Singer

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Please note:

These studies may involve findings that exceed the claims currently cleared by the FDA for the product. Argentum Medical, LLC is not intending to make performance claims about its product. The intent is to disseminate the scientific literature on these products. We encourage you to read these studies to understand the strengths and limitations of the data. For some claims, Argentum is seeking to broaden the indications with the FDA in the future using data, such as these studies, to provide the substantiation.

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